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Adverse Effects of the AstraZeneca/Oxford Covid-19 Vaccine: A Literature Review
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Minoo Mohraz   , Hassan Jalili , Maryam Shafaati , Payam Tabarsi , Mohammadreza Salehi |
| Research center for antibiotic stewardship & antimicrobial resistance, Tehran University of Medical Sciences |
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Abstract: (141 Views) |
| The Covid-19 pandemic had a devastating impact on public health and the social and economic indexes of people around the world. One of the most important approaches to control the Covid-19 pandemic was vaccination. several vaccines using different technologies and platforms were produced and subjected to numerous preclinical and clinical trials. The University of Oxford and the British-Swedish pharmaceutical company "AstraZeneca" were able to develop and introduce a Covid-19 vaccine based on the chimpanzee adenoviral vector previously known as ChAdOx1nCoV-19 and now called AZD1222. This vaccine is commonly known as AstraZeneca vaccine. The aim of this study is to investigate the side effects reported for this vaccine in the literature. In this review, the literature was searched for articles from January 1, 2020 to July 1, 2024, and all types of articles were studied. Relevant keywords were then searched and articles that focused on vaccine side effects or reported side effects of the AstraZeneca vaccine were included. The results revealed: First, the rate and type of side effects mentioned in the studies after general vaccination were more than the cases reported and predicted in the preliminary clinical trials of the vaccine. Second, common serious side effects reported from the AstraZeneca vaccine were neurological diseases, including cerebral venous sinus thrombosis, hemorrhagic stroke, Guillain-Barre syndrome, and transverse myelitis. Last, the most serious complication of this vaccine has been thrombotic thrombocytopenia, which has resulted in the death of patients in some cases, and its rate is 0.73 out of every 100,000 people receiving the first dose of the vaccine. Although this vaccine was removed from the general vaccination program in some countries, including the United Kingdom, in a relatively short period after launched, it was used in many countries until 2024. Perhaps it was appropriate that the international health organizations replaced this vaccine and other vaccines with similar platforms with the Covid-19 vaccines with other platforms in 2021, considering the complications reported. |
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| Keywords: Covid-19, AstraZeneca vaccine, side effects, adenovirus vaccine vector |
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Full-Text [PDF 1123 kb]
(79 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2025/03/10 | Accepted: 2024/07/31 | Published: 2024/07/31
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