|
Association Between Black Tea Consumption and Liver Steatosis and Fibrosis in Patients with Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD) Using Transient Elastography
|
Asieh Mansour   , Atefeh Amrollahi Bioki , Sayed Mahmoud Sajjadi-Jazi |
| Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute |
|
|
Abstract: (167 Views) |
Background and aims: There is emerging evidence that tea has beneficial effects and bioactive compounds, and an increasing number of studies have been conducted regarding tea consumption and health outcomes. However, most of these studies are on green tea and coffee, and few studies have been conducted on black tea. Therefore, the aim of this study is to investigate the relationship between black tea consumption and the severity of steatosis and liver fibrosis in patients with type 2 diabetes (T2DM) and non-alcoholic fatty liver disease (NAFLD).
Methods: In this cross-sectional study, which was conducted on patients with T2DM and NAFLD, the effect of tea intake on liver steatosis and fibrosis was investigated by transient elastography (TE). Tea consumption was estimated by a validated food frequency questionnaire. Patients were classified according to the severity of steatosis and liver fibrosis: steatosis above 66% and F ≥2 were considered as severe steatosis and moderate to severe fibrosis, respectively. Univariate and multivariate regression models were used to analyze the data considering potential confounding factors.
Results: 108 patients with T2DM and NAFLD participated in this study. The mean ± standard deviation (SD) of the patients for age, body mass index (BMI), fasting blood sugar and glycosylated hemoglobin (HbA1c) were 44.69 ± 5.56 years, 30.71 ± 3.82 kg/m2, 152.46 ± 51.94 mg/dL, and 8.33±3.95%, respectively. In this cross-sectional study, high black tea consumption was associated with a lower proportion of clinically significant liver steatosis (>S3) after adjusting for age, sex, BMI, smoking, physical activity, HbA1c, total cholesterol, triglyceride and high-density lipoprotein (HDL) (P=0.009). Compared to less than 3 cups, consumption of 3 to 5 cups or more than 5 cups of black tea per day was associated with a 73% (odds ratio [OR] 0.27, 95% confidence interval [CI]: 0.09–0.89) and 81% (OR 0.19, 95% CI: 0.05–0.76) reduction in the odds of liver steatosis, respectively. No association was demonstrated between tea consumption and the severity of liver fibrosis (P>0.05).
Conclusion: Thus, for T2DM patients with NAFLD, higher intake of black tea is associated with less severe hepatic steatosis.
|
|
| Keywords: non-alcoholic fatty liver disease, type 2 diabetes, liver steatosis, fibrosis, black tea |
|
|
Full-Text [PDF 1426 kb]
(82 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2025/03/10 | Accepted: 2024/07/31 | Published: 2024/07/31
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
