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Relationship Between Fractional Exhaled Nitric Oxide (FeNO), Forced Expiratory Volume in One Second (FEV1), and Asthma Control Test (ACT) Score in Asthmatic Patients
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Elnaz Ezzati   , Keivan Gohari Moghadam , Rasoul Aliannejad , Mahnaz Pejman Sani , Marjan Akhavan |
| Endocrinology and Metabolism Research Center |
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Abstract: (29 Views) |
Background: The primary goal of asthma management is to achieve and maintain clinical control of the disease. In patients with asthma, the presence of various factors influencing disease control highlights the importance of monitoring treatment response through measures beyond clinical criteria. Pulmonary function indices such as forced expiratory volume in one second (FEV1) and fractional exhaled nitric oxide (FeNO) play a role in assessing asthma severity and control. The Asthma Control Test (ACT) is also a validated tool for evaluating disease control levels in these patients. This study aimed to assess asthma control status based on ACT scores, spirometry results, and FeNO levels, while examining correlations among these indicators.
Methods: This cross-sectional study was conducted on adult asthma patients visiting the spirometry unit at Dr. Shariati Hospital, Tehran. Patients completed the ACT questionnaire, and were categorized into three groups based on the Global Initiative for Asthma (GINA) criteria: well-controlled, partially controlled, and uncontrolled asthma. Subsequently, the patients underwent spirometry, and their FeNO levels were measured.
Results: The study included 92 asthma patients (52 women and 40 men), who were categorized into three groups based on their level of asthma control: uncontrolled (n=38), partially controlled (n=27), and well-controlled (n=27). The mean age of participants was 46.18±14.58 years. There were no significant differences between groups in terms of age, gender, regular medication use, history of atopy, family history of asthma, smoking status, or corticosteroid use
(P > 0.05). Patients with well-controlled asthma had significantly higher FEV1 values than other groups (P=0.025), while no significant difference was observed in FEV1/FVC (P=0.141). FeNO levels were significantly higher in the uncontrolled asthma group compared with other groups (P=0.026), and were also higher in men than in women (P=0.007). Correlation analysis showed a weak but significant inverse correlation between FeNO and FEV1 (r=-0.262, P=0.019), as well as between FeNO and ACT scores (r=-0.230, P=0.028). A weak positive correlation was observed between FEV1 and ACT scores (r=0.229, P=0.041).
Conclusion: An inverse correlation was found between FeNO levels and both FEV1 values and ACT scores, while a positive correlation was observed between FEV1 values and ACT scores. These findings emphasize the importance of spirometry in clinical follow-up of asthma patients. Additionally, FeNO levels can serve as a biomarker for asthma control alongside pulmonary function parameters. |
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| Keywords: Asthma, Asthma Control Test, Fractional Exhaled Nitric Oxide, Forced Expiratory Volume in One Second, Spirometry |
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Full-Text [PDF 933 kb]
(11 Downloads)
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Type of Study: Applicable |
Subject:
General
Received: 2025/08/9 | Accepted: 2025/01/29 | Published: 2025/01/29
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