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Evaluating the Relationship between Increased QT Interval and Non-alcoholic Fatty Liver Disease
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Farahnaz Nikdoost   , Amir Anoushirvani |
| Department of Cardiology |
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Abstract: (30 Views) |
Background: Non-alcoholic fatty liver disease (NAFLD) has a relatively high prevalence and is associated with numerous complications. Cardiovascular complications are significant, as they can lead to mortality. Limited studies are available on the association between NAFLD and cardiac rhythm disorders. In this study, the association between prolonged QT interval with NAFLD was investigated.
Methods: This analytical-cross-sectional study involved 200 patients who were referred for liver ultrasound at Shariati Hospital in Tehran in 2023 were selected according to the inclusion criteria. Demographic information, laboratory results and QTc intervals were compared between individuals with and without NAFLD.
Results: The findings revealed that 69 individuals (34.5%) had NAFLD, with 56 (81.1%) classified as mild type and 13 (19.9%) as moderate type. The mean and standard deviation of QTc in patients with NAFLD was significantly higher than those without NAFLD (446.46 ± 14.39 vs. 427.58 ± 14.49 milliseconds and p < 0.001). Moreover, the prevalence of increased QTc in patients with NAFLD was significantly higher than that of non-afflicted patients (73.9% vs. 21.4% and p < 0.001). After adjusting the existing independent and background variables, long QTc interval had a significant and positive relationship with NAFLD (p < 0.001, 95% CI: 1.21-4-86 and OR = 1.48).
Conclusion: Considering the relationship between QT interval increase and NAFLD, appropriate measures and programs can reduce the risk of further complications in high-risk patients. Timely prevention via planning necessary interventions can avert the development of adverse effects. |
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| Keywords: Arrhythmia, Non-alcoholic fatty liver, QTc interval |
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Full-Text [PDF 625 kb]
(12 Downloads)
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Type of Study: Applicable |
Subject:
General
Received: 2025/08/8 | Accepted: 2024/07/31 | Published: 2024/07/31
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