fa ارزیابی ارتباط افزایش فاصله QT با بیماری کبد چرب غیرالکلی عمومى General كاربردي Applicable <span style="font-size:8pt"><span style="line-height:18pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-0.15pt"><b><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">زمینه و هدف:</span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> بیماری کبد چرب غیرالکلی </span></span>(NAFLD)<span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> شیوع نسبتاً بالایی داشته و با عوارض متعددی همراه است. یکی از عوارض مهم آن که پیامد مرگ‌ومیر را نیز در پی دارد، عوارض قلبی‌عروقی است. مطالعات پیرامون ارتباط </span></span>NAFLD<span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> با اختلالات ریتم قلب اندک است. در این مطالعه ارتباط افزایش فاصله </span></span>QT <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">با </span></span>NAFLD<span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> مورد بررسی قرار گرفته است.</span></span></span></span></span></span></span></span><br> <span style="font-size:8pt"><span style="line-height:18pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-0.15pt"><b><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">روش:</span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> در این مطالعه تحلیلی- مقطعی، 200 نفر از بیماران مراجعه&shy;کننده جهت انجام سونوگرافی کبد در بیمارستان شریعتی تهران در سال 1402، طبق معیارهای ورود، به روش در دسترس انتخاب شدند. اطلاعات دموگرافیک، نتایج آزمایشگاهی و فواصل </span></span>QTc <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">بین افراد مبتلا و غیرمبتلا به </span></span>NAFLD <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">مورد مقایسه قرار گرفت.</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:8pt"><span style="line-height:18pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-0.15pt"><b><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">یافته‌ها:</span></span></b><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> در این مطالعه، 69 نفر (5/34 درصد)، مبتلا به </span></span>NAFLD <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">بودند که از این بین، 56 نفر (1/81 درصد) مبتلا به نوع خفیف و 13 نفر (9/19 درصد)، مبتلا به نوع متوسط آن بودند. </span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">میانگین و انحراف معیار </span></span>QTc<span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> در بیماران مبتلا به </span></span>NAFLD <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">در مقابل افراد غیرمبتلا، با تفاوت معنی&shy;داری بالاتر بود (39/14 </span></span><span lang="FA" style="font-size:9.0pt">&plusmn;</span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> 46/446 در مقابل 49/14 </span></span><span lang="FA" style="font-size:9.0pt">&plusmn;</span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> 58/427 میلی ثانیه و 001/0 </span></span>< p<span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">).</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">شیوع </span></span>QTc<span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> افزایش&shy;یافته در بیماران مبتلا به </span></span>NAFLD <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">با تفاوت معنی‌داری بالاتر از افراد غیرمبتلا بود (9/73 در مقابل 4/21 درصد و 001/0 </span></span>< p<span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">). پس از تعدیل متغیرهای مستقل و زمینه&shy;ای موجود، فاصله </span></span>QTc <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">طولانی، ارتباط معنی&shy;دار و مثبتی با ابتلا به </span></span>NAFLD <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">داشت (001/0 </span></span>< p<span style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> ، 86/4 </span></span><span lang="FA" style="font-size:11.0pt">&ndash;</span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> 21/1 :</span></span>CI<span style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"> 95 درصد و 48/1 = </span></span>OR<span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:">).</span></span><span lang="FA" style="font-size:11.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br> <span style="font-size:8pt"><span style="line-height:18pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-0.15pt"><b><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="letter-spacing:0pt">نتیجه‌گیری:</span></span></span></b> <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="letter-spacing:0pt">با توجه به </span></span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="letter-spacing:0pt">ارتباط افزایش فاصله </span></span></span><span dir="LTR" style="letter-spacing:0pt">QT</span> <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="letter-spacing:0pt">با ابتلا به </span></span></span><span dir="LTR" style="letter-spacing:0pt">NAFLD</span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="letter-spacing:0pt">، می&shy;توان با اقدامات و برنامه‌های مناسب خطر ابتلا به عوارض بیشتر را در بیماران در معرض خطر بالاتر کاهش داد و </span></span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="letter-spacing:0pt">جهت انجام مداخلات مورد نیاز، برنامه‌ریزی کرد تا با پیشگیری به&shy;موقع، از ایجاد عوارض ناگوار جلوگیری شود.</span></span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="letter-spacing:0pt"></span></span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:12pt"><span style="line-height:12.0pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt">Background:</span></b><span style="font-size:10.0pt"> Non-alcoholic fatty liver disease (NAFLD) has a relatively high prevalence and is associated with numerous complications. Cardiovascular complications are significant, as they can lead to mortality. Limited studies are available on the association between NAFLD and cardiac rhythm disorders. In this study, the association between prolonged QT interval with NAFLD was investigated.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:12.0pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt">Methods:</span></b><span style="font-size:10.0pt"> This analytical-cross-sectional study involved 200 patients who were referred for liver ultrasound at Shariati Hospital in Tehran in 2023 were selected according to the inclusion criteria. Demographic information, laboratory results and QTc intervals were compared between individuals with and without NAFLD.</span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:12.0pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt">Results:</span></b><span style="font-size:10.0pt"> The findings revealed that 69 individuals (34.5%) had NAFLD, with 56 (81.1%) classified as mild type and 13 (19.9%) as moderate type. The mean and standard deviation of QTc in patients with NAFLD was significantly higher &nbsp;than those without NAFLD (446.46 &plusmn; 14.39 vs. 427.58 &plusmn; 14.49 milliseconds and p < 0.001). Moreover, the prevalence of increased QTc in patients with NAFLD was significantly higher than that of non-afflicted patients (73.9% vs. 21.4% and p < 0.001). After adjusting the existing independent and background variables, long QTc interval had a significant and positive relationship with NAFLD (p < 0.001, 95% CI: 1.21-4-86 and OR = 1.48).</span></span></span></span><br> <b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Considering the relationship between QT interval increase and NAFLD, appropriate measures and programs can reduce the risk of further complications in high-risk patients. Timely prevention via planning necessary interventions can avert the development of adverse effects.</span></span> آریتمی, فاصله QTc, کبد چرب غیرالکلی Arrhythmia, Non-alcoholic fatty liver, QTc interval 0 0 http://idap.ir/browse.php?a_code=A-10-2-8&slc_lang=fa&sid=1 Farahnaz Nikdoost فرحناز نیک‌دوست 100319475328460065 100319475328460065 Yes Department of Cardiology گروه قلب و عروق Amir Anoushirvani امیر انوشیروانی 100319475328460066 100319475328460066 No Depertement of Gastroenterology and Hepatology گروه داخلی فرزاد مسعود کبیر 100319475328460067 100319475328460067 No Department of Cardiology گروه قلب و عروق حامد طاهری 100319475328460068 100319475328460068 No Department of Cardiology گروه قلب و عروق